At the World Economic Forum in Davos on January 23, Musk’s speech once again aroused heated discussion-he bluntly stated that “human beings will eventually find a way to reverse aging.” What supports this view is his insight into the rhythm of life: “There must be some kind of ‘clock’ in your body that synchronously regulates the aging process of approximately 35 trillion cells.” This speech at the world’s top economic forum struck a chord with people about the mechanism of life, and coincided with the cutting-edge discoveries of modern skin care science.

The root cause of skin care dilemma: disrupted skin “biological clock”

In the fast-paced modern life, staying up late, being stressed, and having irregular work and rest schedules have long become the norm. What follows is a series of problems such as fragile skin barriers, collapsed moisturizing power, and dull skin. Many people fall into the skin care dilemma of “external supplements are ineffective”: no matter how many facial masks they apply, the moisture will still be lost quickly; no matter how thick the cream is, the skin will still be dry and peeling.

In fact, behind this is an imbalance of the skin’s circadian rhythm. The skin’s “biological clock” follows the natural logic of “morning P and evening R”:

• During the day: The CLOCK/BMAL1 complex activates protective genes and builds a barrier “protective shield” to resist external stimuli such as ultraviolet rays and oxidation;
• Nighttime: PER/CRY protein dominates the repair mode, focusing on repairing damage during the day and restarting moisturizing and metabolic functions.

Once this rhythm is broken, the skin’s barrier function declines and its ability to repair itself declines, making it difficult for even expensive skin care products to work. The “internal clock” mentioned by Musk at the Davos Forum, when viewed in the field of skin, corresponds to this group of precisely coordinated clock genes-their stable operation is the core code for skin to maintain a healthy state.

Nobel Prize-winning homologous technology: the power of rhythm regulation by the time and space immortal plant

The regulatory mechanism of skin clock genes has long been scientifically proven. The 2017 Nobel Prize in Physiology or Medicine revealed the molecular mechanism of the biological clock and confirmed the mystery of how core clock genes such as CLOCK and BMAL1 regulate circadian rhythm through feedback loops. The research and development of RunR™ Time and Space Fairy Strain is based on this Nobel Prize-winning theory of homology, and it is also blessed with an exclusive invention patent (Patent No.: ZL201710901496.3). It is different from ordinary Dendrobium officinale raw materials on the market and has become a “precise weapon” for regulating skin clock genes.

Effect of Time and Space Fairy Strain on Clock Gene Expression

This regulatory effect was further verified in cell experiments: Cell scratch experiments showed that under the action of the Space-Time Fairy Strain, the change rate of cell scratch width during the night time period (0-6h and 18-24h) was significantly higher than that during the day, proving that it can accurately drive nighttime repair of keratinocytes and resynchronize skin physiological activities with the day and night cycle.

Cell scratch width change rate

Endogenous hydration revolution: Activate the “core hub” of skin moisturizing

While regulating rhythm, RunR™ Time and Space Fairy Strain also overcomes the key problem of “endogenous hydration”. Aquaporin (AQP), which was discovered by the Nobel Prize in Chemistry in 2003, revealed the core mechanism of transmembrane transport of water molecules. As the “core hub” of skin moisturizing, AQP3 directly determines water content and barrier function.

Unlike traditional exogenous water replenishment, which only replenishes water on the surface and is easily lost, Time and Space Fairy Strain achieves the dual effect of “replenishing water + retaining water” by activating AQP3 aquaporin. Experimental data shows that it can increase the expression of AQP3 by 50%, mediate the directional transport of water molecules from the dermis to the epidermis, and transport moisturizing factors such as glycerol at the same time, firmly locking in moisture through the “water-glycerol co-transport mechanism”.

AQP3 protein expression

Note: The stronger the green fluorescence, the higher the AQP3 content. The RunR™ Spacetime Fairy Strain Group showed higher fluorescence intensity in both cells and three-dimensional skin.

Raw materials and technology: the dual ingenuity of the power of plant extracts

This outstanding effect comes from the dual ingenuity of raw materials and technology.

• Raw materials: RunR™ Time and Space Fairy Plant selects Dendrobium officinale from Yunnan’s high-altitude, high-humidity, high-negative-oxygen-imitation wild planting base. It is cultivated using the living tree epiphytic method for 3-5 years. Its polysaccharide content exceeds 40%, which is much higher than wild Dendrobium (20%-30%).
• Process end: Through a unique wall-breaking extraction process and orthogonal experiment optimization, the outer structure of dendrobium stems and leaves is broken, the active ingredients are retained to the greatest extent, and the polysaccharide yield is as high as 10.44mg/ml.

As a “formulated tiger balm”, it is suitable for multiple systems such as lotions, creams, essences, and facial masks. It can still maintain the transparency of the formula at high dosages, take into account both skin feel and efficacy, and provides the beauty industry with a raw material selection that is both technological and practical.

New trends in skin care: Rhythm regulation leads the future skin care revolution

Musk’s “life clock” remarks at the Davos Forum make us re-examine the deep connection between body rhythm and health. In the field of skin care, from “blind external supplementation” to “precisely regulating internal rhythms” is the inevitable trend of technological skin care.

Inspired by Nobel Prize-winning science, RunR™ uses the power of plant extracts to regulate clock genes and activate the endogenous moisturizing mechanism. It not only solves the current pain points of rhythmic skin care for young people, but also opens up a new two-dimensional skin care path of “rhythm regulation + endogenous moisturizing”. In the future, with the in-depth research on skin biological clock, more precise skin care solutions based on gene regulation will continue to emerge, and RunR™ Time and Space Fairy Plant is becoming a pragmatic explorer in this trend with its solid scientific research and measured efficacy, using technology to inject precise power into beauty and skin care.