Nowadays, photodamage has become a hot topic, which not only causes skin aging and affects the appearance, but may also cause serious health problems. Mid-wave ultraviolet (UVB) is a key factor in inducing skin photodamage. It can activate keratinocytes to produce inflammatory factors (such as IL-1α, PGE2), leading to erythema, blisters and other injuries. The team of Professor Li Li of Landivine Research Institute published a study in the China Science and Technology Core Journal “Food and Fermentation Industry”, reporting for the first time that Ganoderma-Chaga freeze-dried powder prepared using liquid two-way fermentation technology has significant efficacy in repairing UVB light damage, providing a new path for the development of efficient anti-photoaging cosmetic raw materials.

Key breakthrough:

1. Targeted inhibition of inflammatory storm: At a safe concentration (0.0313 mg/mL), Ganoderma-Chaga (S3) fermentation liquid freeze-dried powder has a very significant inhibitory rate on the secretion of key inflammatory factors IL-1α and PGE2 by HaCaT cells induced by UVB, directly attacking the core mechanism of photodamage.
2. The synergistic effect is clear: the efficacy of Ganoderma-Chaga fermentation combination (S3) is significantly better than that of Ganoderma fermentation alone (S1), especially in inhibiting the strong inflammatory and pain-causing factor PGE2, the effect of S3 is significantly stronger than that of S1 (P<0.01).
3. Chaga is the key synergist: Through research and comparison of five fermentation broth freeze-dried powders of Ganoderma (S1), Ganoderma-Polygonatum odoratum (S2), Ganoderma-Chaga (S3), Ganoderma-ginseng (S4), and Ganoderma-Panax notoginseng (S5), it was determined that Chaga is the key synergistic ingredient to improve the photodamage repair ability of Ganoderma fermentation products, revealing the potential of specific bacterial and drug combinations in metabolic regulation.

IL-1α content detection results

Effect of S1 ~ S5 on IL-1α secretion content

PGE2 test results

Effect of S1 ~ S5 on PGE2 secretion content

Scientific and technological value and industrialization prospects:

1. Innovative technical barriers: “Medicinal fungi + characteristic plants” two-way fermentation technology can achieve directional transformation and enrichment of highly active ingredients, breaking through the bottleneck of the traditional single Ganoderma raw material efficacy.
2. Outstanding raw material advantages: The obtained S3 freeze-dried powder has stable activity, clear dose effect, and high biological safety, which meets the demand for functional raw materials in high-end anti-photoaging, after-sun repair and soothing skin care products.
3. Solid foundation for industrialization: This process has the advantages of large-scale production such as short cycle, large output, controllable cost, and uniform quality, laying the foundation for the development of “fermentation source” targeted anti-photoaging raw materials with independent intellectual property rights.

Research summary:

This study successfully selected Ganoderma-Chaga two-way fermentation (S3) as the optimal anti-UVB damage combination, and confirmed its efficient repair mechanism through cell models. This not only provides scientific and technological support for the high-value utilization of Ganoderma and Chaga resources, but also opens up a new path for the development of the next generation of efficient, green, and targeted cosmetic active ingredients, which is of great significance to enhancing industrial competitiveness.